Table 33 SSRIs for children and adolescents with Bulimia Nervosa
From: Canadian practice guidelines for the treatment of children and adolescents with eating disorders
| Certainty assessment | Impact | Certainty | Importance | ||||||
|---|---|---|---|---|---|---|---|---|---|
| № of studies | Study design | Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | |||
| Binge Frequency (assessed with: average weekly binges), purge frequency, psychological symptoms, depression (BDI) | |||||||||
| 1 | Case Series | very serious a | not serious | not serious | not serious | none | Ten subjects all female, no control group. 8 week study of fluoxetine 60 mg/day. Binge frequency decreased from 4.1 to 3.8 (p < 0.01). Purge frequency decreased from 6.4 to 5.2 (p < 0.005). | ⨁◯◯◯ VERY LOW | CRITICAL |
| very serious a | not serious | not serious | not serious | none | EDI Bulimia Subscale decreased significantly from 10.6 to 4.2 (P < 0.01). | ⨁◯◯◯ VERY LOW | CRITICAL | ||
| very serious a | not serious | not serious | not serious | none | BDI scores were not significantly different pre and post. | ⨁◯◯◯ VERY LOW | CRITICAL | ||
| Adverse Effect - Mania | |||||||||
| 1 | Case Report | very serious a,b | not serious | not serious | not serious | none | Case described of teen with BN treated with fluoxetine 20 mg who developed mania - fluoxetine stopped and valproate started. | ⨁◯◯◯ VERY LOW | CRITICAL |